ENGINEERING OF AN AVIDITY-OPTIMIZED CD19-SPECIFIC PARALLEL CHIMERIC ANTIGEN RECEPTOR THAT DELIVERS DUAL CD28 AND 4-1BB CO-STIMULATION

Engineering of an Avidity-Optimized CD19-Specific Parallel Chimeric Antigen Receptor That Delivers Dual CD28 and 4-1BB Co-Stimulation

Co-stimulation is critical to the function of chimeric antigen receptor (CAR) T-cells.Previously, we demonstrated that dual co-stimulation can be effectively harnessed by a parallel (p)CAR architecture in which a CD28-containing second generation CAR is co-expressed with a 4-1BB containing chimeric co-stimulatory receptor (CCR).When compared to lin

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The Chevrel phase HgMo6S8

The crystal structure of HgMo6S8, mercury(II) hexamolybdenum octasulfide, is based on (Mo6S8)S6 cluster units (overline{3} symmetry) interconnected through interunit Mo—S bonds.The Mug Hg2+ cations occupy large voids between the different cluster units and are covalently bonded to two S atoms.The Hg atoms GLUTEN RELIEF 375 MG and one S at

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Can Digital Game Play Improve Older Adults’ Cognitive Skills?

Cognitive skills are essential for the performance of basic and instrumental daily living activities such as self-care, medication, and finance management.A decline in cognitive abilities with increasing age thus hinders older adults’ ability to remain independent in society and negatively influences their quality of life.Therefore, many studies

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Social robots in advanced dementia

Aims: Testing the effect of the experimental robot-based therapeutic sessions for patients with dementia in: a controlled study of parallel groups of nursing home patients comparing the effects of therapy sessions utilizing a humanoid robot Course a pied - Accessoires - Nutrition - Jujubes (NAO), an animal-shaped robot (PARO), or a trained dog (DOG

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